Dexacortone 0,5 mg 100 tabletten

Dexacortone 0.5 mg tablets

Dexacortone is a chewable tablet containing 0.5 mg of the glucocorticoid dexamethasone. It is indicated for the symptomatic treatment or as an adjunct treatment of inflammatory and allergic conditions in dogs and cats.

Corticoid administration is to induce an improvement in clinical signs rather than a cure. The treatment should be combined with treatment of the underlying disease and/or environmental control.

Pharmacodynamics
Dexamethasone is a long-acting glucocorticosteroid; its potency is about 25 times greater than the short-acting substances, such as hydrocortisone. Glucocorticoids play a role in carbohydrate-, protein- and fat metabolism, and have an antiphlogistic and immunosuppressive effect. The main effect of glucocorticosteroids is the ability of these products to suppress inflammatory reactions, independent of the cause of the inflammation (infectious, allergic, chemical, mechanical). Thanks to the ability to inhibit phospholipase enzymes in the cell membranes, the formation of prostaglandins and leukotrienes is prevented.

Pharmacokinetics
Following oral administration dexamethasone is well absorbed in dogs and cats. In plasma, dexamethasone is present in free form and bound to plasma proteins. In the liver, corticosteroids like dexamethasone are metabolised (glucuronidated and sulfated), therefore only a small amount of the active substance can be traced in the urine.